Previcox efficacy

Efficacy of cyclo-oxygenase inhibition by two commercially available firocoxib products in horses

Article first published online: 16 JUL 2013 Equine Veterinary Journal

Results

In the control group, there was no significant change in LPS-induced PGE₂ over time. In contrast, immediately prior to and 1 h after treatment on Day 7, the mean LPS-induced PGE₂ concentration decreased significantly compared to Day 0 values in all treated horses. There was no difference in PGE₂ or plasma firocoxib concentrations between firocoxib treatment groups.

Conclusion

In this model, the canine chewable preparation of firocoxib was as effective as the equine paste formulation at reducing LPS-induced PGE₂ synthesis.

Potential relevance

The canine chewable preparation of firocoxib may be a suitable alternative to the paste formulation in horses for situations where extra-label drug use can be legally justified.